abstract：:Ethylenediaminetetraacetic acid (EDTA) is widely used in food and other industries to sequester metal ions and to prevent their disadvantageous effects. The objective of the current study was to evaluate the protective effect of Panax ginseng extract standardized with ginsenoside Rg3 (ginsenoside Rg3 content was 3.6% ...

journal_title：Archives of toxicology

authors： Khalil WK,Ahmed KA,Park MH,Kim YT,Park HH,Abdel-Wahhab MA

更新日期：2008-03-01 00:00:00

abstract：:Xenobiotic induced liver injury is a leading cause for drug withdrawal and toxicogenomics may help to identify molecular causes. Here we report studies with cultures of human hepatocytes to detect early responses of liver toxicity upon treatment with the hepatotoxin Aroclor 1254. We studied transcript abundance of 302...

journal_title：Archives of toxicology

authors： Thum T,Borlak J

更新日期：2008-02-01 00:00:00

abstract：:N-Methyl-2-pyrrolidone (NMP) is a versatile organic solvent frequently used for surface cleaning such as paint stripping or graffiti removal. Liquid NMP is rapidly absorbed through the skin but dermal vapour phase absorption might also play an important role for the uptake of the solvent. This particular aspect was in...

journal_title：Archives of toxicology

authors： Bader M,Wrbitzky R,Blaszkewicz M,Schäper M,van Thriel C

更新日期：2008-01-01 00:00:00

abstract：:Sulfur dioxide (SO2) is a common air pollutant, and inhaled SO2 in airway epithelium easily forms its soluble derivatives in vivo (bisulfite and sulfite), which are toxic to the respiratory system and related to the exacerbation of asthma. To investigate the effects of SO2 derivatives on the expressions of asthma rela...

journal_title：Archives of toxicology

authors： Li R,Meng Z

更新日期：2007-12-01 00:00:00

abstract：:Most dietary flavonoids have antioxidant activity in vitro however, secondary mechanisms such as the ability to influence gene expression with the consequent modulation of specific enzymatic activities involved in the intracellular response against oxidative stress, are being realized. In the following study, we exami...

journal_title：Archives of toxicology

authors： Mitchell AE,Burns SA,Rudolf JL

更新日期：2007-11-01 00:00:00

abstract：:The involvement of oxidative stress has been suggested as a mechanism for neurotoxicity caused by methylmercury (MeHg), but the mechanism for MeHg selective toxicity in the central nervous system is still unclear. In this research, to clarify the mechanism of selective neurotoxicity caused by MeHg, the oxygen consumpt...

journal_title：Archives of toxicology

authors： Mori N,Yasutake A,Hirayama K

更新日期：2007-11-01 00:00:00

abstract：:Cytochrome P4502E1 (CYP2E1) gene shows genetic polymorphisms that vary markedly in frequency among different ethnic and racial groups. We studied the genotype distributions and allele frequencies of three CYP2E1 polymorphisms: CYP2E1*5B (RsaI/PstI RFLP, C-1053T/G-1293C SNP, rs2031920 /rs3813867), CYP2E1*6 (DraI RFLP, ...

journal_title：Archives of toxicology

authors： Ulusoy G,Arinç E,Adali O

更新日期：2007-10-01 00:00:00

abstract：:Acetaminophen (APAP) is a widely-used analgesic and a known hepatotoxic agent. Vascular endothelial growth factor (VEGF) is a growth factor with multiple functional roles. VEGF plays an important role in angiogenesis and hepatic regeneration. The aim of this study was to determine the expression of VEGF isoforms and i...

journal_title：Archives of toxicology

authors： Papastefanou VP,Bozas E,Mykoniatis MG,Grypioti A,Garyfallidis S,Bartsocas CS,Nicolopoulou-Stamati P

更新日期：2007-10-01 00:00:00

abstract：:Cytokeratins (CK) constitute a family of cytoskeletal intermediate filament proteins that are typically expressed in epithelial cells. An abnormal structure and function are effects that are clearly related to liver diseases as non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma. We have previously o...

journal_title：Archives of toxicology

authors： Gonsebatt ME,Del Razo LM,Cerbon MA,Zúñiga O,Sanchez-Peña LC,Ramírez P

更新日期：2007-09-01 00:00:00

abstract：:Iron (Fe) plays essential roles in biological processes, whereas cadmium (Cd) is a toxic and non-essential metal. Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals. Here, we studied the effect of dietary Fe on the expression ...

journal_title：Archives of toxicology

authors： Kim DW,Kim KY,Choi BS,Youn P,Ryu DY,Klaassen CD,Park JD

更新日期：2007-05-01 00:00:00

abstract：:A number of studies have evaluated the possibility that stress-induced changes in blood-brain barrier permeability enhanced the central effects of the carbamate acetylcholinesterase inhibitor, pyridostigmine. We previously found relatively little evidence of stress-induced changes in the acute toxicity of pyridostigmi...

journal_title：Archives of toxicology

authors： Baireddy P,Mirajkar N,Nallapaneni A,Singleton N,Pope CN

更新日期：2007-04-01 00:00:00

abstract：:Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...

journal_title：Archives of toxicology

authors： Aluoch AO,Odman-Ghazi SO,Whalen MM

更新日期：2007-04-01 00:00:00

abstract：:Dulcin (DL), now banned, was once a widely used artificial sweetener. DL possesses an ureido group that is metabolized by direct glucuronidation in rabbit liver microsomes. Dulcin N-glucuronide (DNG) is the only type of ureido N-glucuronide known to date; ureido glucuronidation in humans has not been previously report...

journal_title：Archives of toxicology

authors： Uesawa Y,Staines AG,Lockley D,Mohri K,Burchell B

更新日期：2007-03-01 00:00:00

abstract：:The effects of acetaldehyde (ACD) on dopamine (DA) and DA-derived salsolinol (SAL) levels were investigated in the striatum of freely moving rats. Dialysate levels of DA and SAL were determined using in vivo reverse microdialysis coupled with high-performance liquid chromatography with an electrochemical detector. Per...

journal_title：Archives of toxicology

authors： Wang W,Ameno K,Jamal M,Kumihashi M,Uekita I,Ameno S,Ijiri I

更新日期：2007-02-01 00:00:00

abstract：:Phytoestrogens have been described as weak estrogens, selective estrogen receptor mediators (SERMs) or to exhibit antiestrogenic properties. However, information about their activity in combination with xenoestrogens and 17beta-estradiol in vivo, is limited. Therefore, the combinatory activity of the phytoestrogen gen...

journal_title：Archives of toxicology

authors： Schmidt S,Degen GH,Seibel J,Hertrampf T,Vollmer G,Diel P

更新日期：2006-12-01 00:00:00

abstract：:Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxicity and prevention. Metabolism and ...

journal_title：Archives of toxicology

authors： Kurebayashi H,Ohno Y

更新日期：2006-12-01 00:00:00

abstract：:Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...

journal_title：Archives of toxicology

authors： Lüersen L,Wellner T,Koch HM,Angerer J,Drexler H,Korinth G

更新日期：2006-10-01 00:00:00

abstract：:Sulfites whether ingested or produced through the sulfur-containing amino acids metabolism of the animal are very active molecules and can cause cellular toxicity. Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabol...

journal_title：Archives of toxicology

authors： Oztürk OH,Küçükatay V,Yönden Z,Ağar A,Bağci H,Delibaş N

更新日期：2006-10-01 00:00:00

abstract：:Our previous study suggested the possibilities that dicyclanil (DC), a nongenotoxic carcinogen, produces oxidative stress in the liver of the two-stage hepatocarcinogenesis model of mice and the stress induced probably causes secondary oxidative DNA damage. However, clear evidences demonstrating the relationship betwe...

journal_title：Archives of toxicology

authors： Moto M,Umemura T,Okamura M,Muguruma M,Ito T,Jin M,Kashida Y,Mitsumori K

更新日期：2006-10-01 00:00:00

abstract：:The tetrahydroxylated biphenyl-ketone 2,2',4,4'-tetrahydroxybenzophenone (BP2), one of twelve benzophenone-derived UV-filters, is used in cosmetic products and in packaging materials to protect these products from light induced damage. Recently published studies showed that BP2 exerts estrogenic activity; thus, it is ...

journal_title：Archives of toxicology

authors： Schlecht C,Klammer H,Wuttke W,Jarry H

更新日期：2006-10-01 00:00:00

abstract：:This study was carried out to investigate the effect of in utero exposure to the cholinotoxicants, nicotine and chlorpyrifos, alone or in combination on neurobehavioral alterations and neuronal morphology latter in adult age. In the present study, 90 days old (corresponding to a human adult age) male and female offspr...

journal_title：Archives of toxicology

authors： Abou-Donia MB,Khan WA,Dechkovskaia AM,Goldstein LB,Bullman SL,Abdel-Rahman A

更新日期：2006-09-01 00:00:00

abstract：:In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark ...

journal_title：Archives of toxicology

authors： Momekov G,Ferdinandov D,Bakalova A,Zaharieva M,Konstantinov S,Karaivanova M

更新日期：2006-09-01 00:00:00

abstract：:To investigate the mechanism on photosensitive dermatitis caused by ketoprofen (KP) in humans, the following experiments were performed by topical application on guinea pigs. The phototoxicity study involving treatment with 10% solution of KP, its enantiomers (R-KP and S-KP), loxoprofen, and flurbiprofen revealed no p...

journal_title：Archives of toxicology

authors： Nakazawa T,Shimo T,Chikamatsu N,Igarashi T,Nagata O,Yamamoto M

更新日期：2006-07-01 00:00:00

abstract：:Teratogenic effects caused by a new nitroimidazopyridazine were examined in Wistar (WU) rats after repeated oral administration of 0, 2.5, 10, and 40 mg/kg, given on days 6-17 post coitum (p.c.) (Day of mating = Day 0) in a regular study on embryo-fetal development according to ICH S5A. At day 20 p.c., fetuses were re...

journal_title：Archives of toxicology

authors： Woehrmann T,Volland J,Tuch K,Bode G,Hübel U

更新日期：2006-07-01 00:00:00

abstract：:The highly directional maternal-to-fetal transfer of essential fatty acids (EFAs) across the placenta plays a critical role in guiding proper fetal development. Exposure to xenobiotics that may alter the fetal supply of EFAs/lipids could lead to fetal toxicity. Since the placenta is the first fetal arising organ that ...

journal_title：Archives of toxicology

authors： Xu Y,Knipp GT,Cook TJ

更新日期：2006-05-01 00:00:00

abstract：:Using human neuroblastoma SH-SY5Y cells, effects of acrylamide on p53 protein and intracellular signal transducting pathways were examined. Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2). The phosphorylation of p53 was specific for the Ser15 site. Among mitogen-a...

journal_title：Archives of toxicology

authors： Okuno T,Matsuoka M,Sumizawa T,Igisu H

更新日期：2006-03-01 00:00:00

abstract：:The present study was carried out to elucidate the mechanisms behind an increase in the incidence of malignant or multiple mammary tumors as a result of oral administration of rolipram in a 104-week carcinogenicity study. The organs and tissues of Sprague-Dawley (SD) rats of both sexes, which had been subjected to a 1...

journal_title：Archives of toxicology

authors： Nishiyama S,Okudaira M,Saito N

更新日期：2006-02-01 00:00:00

abstract：:A new class of potent anticancer drugs, alkylphosphocholines has been recognized lately. Miltefosine (Hexadecylphosphochlorine, HPC) has been found to express select antineoplastic effect on human breast cancer skin metastases with simultaneous preservation of bone marrow proliferative activity and low clastogenicity....

journal_title：Archives of toxicology

authors： Martinova Y,Topashka-Ancheva M,Konstantinov S,Petkova S,Karaivanova M,Berger M

更新日期：2006-01-01 00:00:00

abstract：:In vivo screening methods for detection of thyroid function modulators are now under development in many research laboratories. We assessed the applicability of the Hershberger assay protocol to screen for thyroid function modulators. In experiment 1, castrated male BrlHan WIST@Jcl (GALAS) rats were administered a pot...

journal_title：Archives of toxicology

authors： Noda S,Muroi T,Takakura S,Sakamoto S,Takatsuki M,Yamasaki K,Tateyama S,Yamaguchi R

更新日期：2005-11-01 00:00:00

abstract：:The results from a survey of the expert information that is publicly accessible on the use of the dog as test species during the regulatory evaluation of agricultural chemicals and pesticides are reported. Methods that are being used or considered in order to reduce the number of dogs used for this purpose are describ...

journal_title：Archives of toxicology

authors： Box RJ,Spielmann H

更新日期：2005-11-01 00:00:00

abstract：:This study investigated whether paraquat (Pq)-induced lipidic peroxidation (LP) is accompanied by changes in blood pressure and heart rate (HR) in rats. Groups of adult male Wistar rats were studied 2 and 12 h after Pq (35 mg/kg, i.p.) administration. The LP was evaluated by monitoring thiobarbituric acid reactive sub...

journal_title：Archives of toxicology

authors： Oliveira MV,Albuquerque JA,Paixão AD,Guedes LS,Cabral AM

更新日期：2005-09-01 00:00:00

abstract：:The effects of diabetes on cytochrome P450 (CYP)-dependent drug metabolizing enzymes are yet to be clarified. The most widely used animals in these studies have been rats, and information on the effects of diabetes on rabbit liver drug metabolizing enzymes have been unavailable until now. In this study, for the first ...

journal_title：Archives of toxicology

authors： Arinç E,Arslan S,Adali O

更新日期：2005-08-01 00:00:00

abstract：:The OECD has developed an "enhanced Test Guideline 407" (TG 407) protocol for detecting endocrine effects during the course of a 28-day testing scheme. This protocol has gone through a validation process with (anti)estrogenic and (anti)androgenic compounds and substances that affect the thyroid (thyroxine and propylth...

journal_title：Archives of toxicology

authors： Cunha GC,van Ravenzwaay B

更新日期：2005-07-01 00:00:00

abstract：:Cyclic AMP (c-AMP), added on its own to rat hepatocyte cultures, caused a marked accumulation of coproporphyrin III. The results obtained by comparing the effect of c-AMP to that of exogenous 5-aminolevulinate (ALA), and from adding c-AMP and ALA together, indicated that the coproporphyrinogen III metabolism was block...

journal_title：Archives of toxicology

authors： De Matteis F,Harvey C

更新日期：2005-07-01 00:00:00

abstract：:The metabolism of arsenic is generally accepted to proceed by repetitive reduction and oxidative methylation; the latter is mediated by arsenic methyltransferase (Cyt19). In human urine, the major metabolites of inorganic arsenicals such as arsenite (iAsIII) and arsenate (iAsV) are monomethylarsonic acid (MMA(V)) and ...

journal_title：Archives of toxicology

authors： Hayakawa T,Kobayashi Y,Cui X,Hirano S

更新日期：2005-04-01 00:00:00

abstract：:Particle-induced carcinogenicity is not well understood, but might involve inflammation. The proinflammatory cytokine tumor necrosis factor (TNF) is considered to be an important mediator in inflammation. We investigated its role in particle-induced inflammation and DNA damage in mice with and without TNF signaling. T...

journal_title：Archives of toxicology

authors： Saber AT,Bornholdt J,Dybdahl M,Sharma AK,Loft S,Vogel U,Wallin H

更新日期：2005-03-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent tumor promoter ever tested in rodents. Although it is known that most of the effects of TCDD are mediated by binding to the aryl hydrocarbon receptor (AhR), the mechanisms leading to tumor promotion still remain to be elucidated. Loss of contact inhibition ...

journal_title：Archives of toxicology

authors： Hoelper P,Faust D,Oesch F,Dietrich C

更新日期：2005-01-01 00:00:00

abstract：:Clark 1 (diphenylarsine chloride) and Clark 2 (diphenylarsine cyanide) were used as chemical weapon agents (CWA), and the soil contamination by these CWA and their degraded products, diphenyl and phenyl arsenicals, has been one of the most serious environmental issues. In a series of comparisons in toxicity between tr...

journal_title：Archives of toxicology

authors： Hirano S,Kobayashi Y,Hayakawa T,Cui X,Yamamoto M,Kanno S,Shraim A

更新日期：2005-01-01 00:00:00

abstract：:In recent years test systems have been described that may be applied routinely to discriminate between contact allergens and irritants in vitro. Using human monocyte-derived dendritic cells (MoDC), this study was designed to refine the settings of a potential routine screening protocol for contact allergens and to inv...

journal_title：Archives of toxicology

authors： Straube F,Grenet O,Bruegger P,Ulrich P

更新日期：2005-01-01 00:00:00

abstract：:Natural and synthetic chemicals are often used in the fragrance industry. A toxicological profile of the synthetic fragrance booster, 4-cycloocten-1-carbaldehyde, was generated using a test program including the following methods: acute oral toxicity, acute dermal toxicity, acute skin and eye irritation, skin sensitiz...

journal_title：Archives of toxicology

authors： Messinger H,Kleber M,Aulmann W

更新日期：2004-12-01 00:00:00